Giovanni Simeone, Giacomo Raspadori and Jesper Lindstrom lead the way for Napoli in the Coppa Italia Round of 16 against Frosinone.
It kicks off at the Stadio Diego Armando Maradona at 20.00 GMT.
The fixture will be decided on the night, after 90 minutes, extra time or even penalties if needed.
The winners of this game will face either Juventus or Salernitana, not finding out which until that game on January 4.
Walter Mazzarri got the Partenopei back on track with victories against Cagliari and SC Braga, setting up a Champions League Round of 16 showdown with Barcelona in February.
Victor Osimhen and Kvicha Kvaratskhelia are among those rested, while Eljif Elmas, Piotr Zielinski, Andre Frank Zambo Anguissa and Mathias Olivera are not fully fit.
It is an opportunity for Simeone, Raspadori and summer signing Lindstrom to prove themselves.
Frosinone are comfortably mid-table in Serie A, but have never beaten Napoli, managing two draws in 10 competitive meetings.
This is the first time the Canarini have ever made it to the Coppa Italia Round of 16.
Luca Mazzitelli, Reinier, Riccardo Marchizza and Sergio Kalaj are injured, but Enzo Barrenechea and Walid Cheddira bring quality to the proceedings.
Napoli: Gollini; Zanoli, Ostigard, Natan, Mario Rui; Cajuste, Demme, Gaetano; Lindstrom, Simeone, Raspadori
Frosinone: Cerofolini; Okoli, Monterisi, Lusuardi, Garritano; Bourabia, Barrenechea, Brescianini; Cheddira, Caso, Kvernadze
Player statistic
| 43' |  |
Mehdi Bourabia | ||
| 45+1' | |
Giorgi Kvernadze |
| Jens Cajuste | |
61' | ||
| 65' |  |
Enzo Barrenechea (Assist: Luca Garritano) | ||
| 70' | |
Giuseppe Caso | ||
| 70' | |
Giuseppe Caso | ||
| Gianluca Gaetano | |
74' | ||
| 80' | |
Abdou Harroui | ||
| Matteo Politano | |
85' | ||
| 89' | |
Ilario Monterisi | ||
| 90+1' | |
Walid Cheddira | ||
| 90+5' | |
Abdou Harroui (Assist: Pol Lirola) |
Match statistic
