It kicks off at San Siro at 20.00 GMT.
This tie will be decided on the night after 90 minutes, or extra time and penalties if needed.
Stefano Pioli still has a massive injury list to deal with, including Mike Maignan, Divock Origi, Fode Ballo-Toure, Zlatan Ibrahimovic, Rade Krunic, Alessandro Florenzi, Simon Kjaer and Ante Rebic.
The coach therefore opts for a change of formation with Rafael Leao and Theo Hernandez rested, moving to a 3-5-2 with De Ketelaere as the False 9 supported by Brahim Diaz.
Torino have plenty of problems too, with former Milan striker Pietro Pellegri joining Ola Aina and Valentin Lazaro on the treatment table.
Tonny Sanabria leads the attack with support from Aleksey Miranchuk and Nikola Vlasic, while Ricardo Rodriguez is shifted into a more advanced role.
Milan: Tatarusanu; Kalulu, Gabbia, Tomori; Saelemaekers, Vranckx, Tonali, Pobega, Dest; De Ketelaere, Brahim Diaz
Torino: Milinkovic-Savic; Djidji, Schuurs, Buongiorno; Singo, Lukic, Ricci, Rodriguez; Miranchuk, Vlasic, Sanabria