Juventus rely on Turkish teenage sensation Kenan Yildiz and Arkadiusz Milik in the Coppa Italia quarter-final, while Frosinone start Juve-owned forward Kaio Jorge.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The winner will be decided tonight, whether it’s after 90 minutes, extra time or even penalties.
Whoever gets through will go on to face Lazio in the two-legged semi-final, while Milan and Fiorentina meet in the other clash.
Juventus are without Federico Chiesa, Adrien Rabiot, Moise Kean and Mattia De Sciglio, while Dusan Vlahovic is on the bench after suffering from flu symptoms this week.
This means Yildiz again gets the nod upfront and this time is partnered by Milik.
Alex Sandro, Andrea Cambiaso and Samuel Iling Junior are not quite at 100 per cent, but are available from the bench.
Federico Gatti and Weston McKennie are suspended in Serie A this weekend, so have no need to rest.
Frosinone already caused a huge upset in the Coppa Italia by beating Napoli 4-0 last time out.
They also troubled Juve in Serie A during their meeting on December 23, as Vlahovic needed a late goal to secure the 2-1 result.
Jaime Baez scored in that game, but is on the treatment table along with Riccardo Marchizza and Sergio Kalaj.
There are quite a few Juventus-owned players on loan with the Canarini, including Kaio Jorge, Matias Soulé and Enzo Barrenechea, but only the Brazilian is starting.
Juventus: Perin; Gatti, Bremer, Danilo; Weah, McKennie, Locatelli, Miretti, Kostic; Milik, Yildiz
Frosinone: Cerofolini; Romagnoli, Okoli, Lusuardi; Garritano, Brescianini, Mazzitelli, Lirola; Harroui, Ibrahimovic; Kaio Jorge
Player statistic
| Arkadiusz Milik |  |
11' | ||
| Manuel Locatelli |  |
20' | ||
| Filip Kostic | |
32' | ||
| Arkadiusz Milik (Assist: Weston McKennie) |
 |
38' |
| Arkadiusz Milik (Assist: Manuel Locatelli) |
|
48' | ||
| Kenan Yıldız (Assist: Weston McKennie) |
|
61' | ||
| Federico Gatti | |
72' |
Match statistic
