Juventus look to Dusan Vlahovic, Paulo Dybala and Giorgio Chiellini as they bid to retain the Coppa Italia, while Lautaro Martinez and Edin Dzeko cannot count on Inter’s Alessandro Bastoni.
It kicks off at the Stadio Olimpico in Rome at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The winner will be decided after 90 minutes, or if needed extra time and even penalties.
Juve are still missing Weston McKennie, Federico Chiesa and Kaio Jorge, while Mattia De Sciglio is suspended.
Manuel Locatelli, Danilo and Luca Pellegrini are available again, but only the Brazilian gets the nod from the start, supporting Vlahovic and soon to be ex-Juventus forward Dybala, who has been linked with a free transfer to Inter.
The captain is Chiellini, who is also likely to leave the Old Lady this summer.
Inter are without Matias Vecino, but the big doubt had been around Alessandro Bastoni, who has not been risked in the starting XI after three weeks out with a calf injury.
Instead, Danilo D’Ambrosio completes the back three, with Ivan Perisic and Matteo Darmian out wide, Lautaro Martinez and Edin Dzeko upfront.
When these sides met for the Supercoppa Italiana in January, Inter won 2-1 in the final seconds of extra time with an Alexis Sanchez strike.
Juventus: Perin; Danilo, De Ligt, Chiellini, Alex Sandro; Zakaria, Rabiot; Cuadrado, Dybala, Bernardeschi; Vlahovic
Juventus bench: Szczesny, Pinsoglio, Arthur, Morata, Pellegrini, Kean, Bonucci, Rugani, Locatelli, Ake, Nicolussi Caviglia, Miretti
Inter: Handanovic; Skriniar, De Vrij, D’Ambrosio; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Lautaro Martinez, Dzeko
Inter bench: Cordaz, Radu, Dumfries, Gagliardini, Sanchez, Ranocchia, Gosens, Correa, Vidal, Dimarco, Caicedo, Bastoni
Alex Sandro is there to ensure Shinter wins.
Well done Allegri.