Roma captain Lorenzo Pellegrini returns, as Roger Ibanez seems set to start at right-back when Jose Mourinho makes big changes for the match against Zorya Luhansk in the Europa League.
The match kicks off at 17.45 UK time.
Roma arrive from a heavy defeat to the local rivals Lazio in Serie A and aim to bounce back immediately.
Ibanez seems set to start at right in a four-man defence, with Chris Smalling and Giuanluca Mancini in the middle.
Jordan Veretout and Bryan Cristante should get rested for the European game, with Amadou Diawara and Gonzalo Villar expected to start, while captain Pellegrini returns in attacking midfield.
Stephan El Shaarawy is ready to contribute, with Eldor Shomurodov spearheading the Giallorossi in Ukraine.
Carles Perez completes the attacking trident behind the former Genoa man, while the hosts are expected to start in a 4-3-3 formation.
Probable line-ups: Zorya vs. Roma
Zorya (4-3-3): Matsapura; Khomchenovskyy, Vernydub, Cvek, Juninho; Nazaryna, Buletsa, Kochergin; Sayyadmanesh, Gromov, Kavaiev
Roma (4-2-3-1): Rui Patricio; Ibanez, Mancini, Smalling, Calafiori; Diawara, Villar; Carles Perez, Pellegrini, El Shaarawy; Shomurodov