Roma must beat Leicester City to reach the Europa Conference League Final, using Nicolò Zaniolo and Lorenzo Pellegrini in support of Tammy Abraham against Jamie Vardy and Youri Tielemans.
It kicks off at the sold out Stadio Olimpico at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
The first leg ended 1-1 at the King Power Stadium last Thursday, with Pellegrini’s opener cancelled out by what was credited as a Gianluca Mancini own goal.
Away goals no longer count for double in Europe, so whoever wins today goes to the Final and a draw would spark extra time.
Henrikh Mkhitaryan is injured, so Sergio Oliveira steps into midfield with Bryan Cristante.
Pellegrini and Zaniolo support centre-forward Abraham.
Leicester City are only missing Wilfried Ndidi and Ryan Bertrand, as James Maddison and Kiernan Dewsbury-Hall both recovered from knocks that saw them miss Sunday’s game with Tottenham Hotspur.
Vardy already started the first leg and has now fully recovered from a knee injury, but ex-Atalanta right-back Timothy Castagne is not at 100 per cent.
Roma: Rui Patricio; Mancini, Smalling, Ibanez; Karsdorp, Sergio Oliveira, Cristante, Zalewski; Zaniolo, Pellegrini; Abraham
Roma bench: Fuzato, Vina, Carles Perez, Shomurodov, Maitland-Niles, Veretout, Kumbulla, Spinazzola, Diawara, Bove, Afena-Gyan, El Shaarawy
Leicester City: Schmeichel; Ricardo Pereira, Fofana, J Evans, Justin; Tielemans; Lookman, Maddison, Dewsbury-Hall, Barnes; Vardy
Leicester bench: Ward, Caglar Soyuncu, Albrighton, Iheanacho, Perez, Amartey, Choudhury, Vestergaard, Castagne, Daka, Thomas, Soumare
Ref: Jovanovic (SRB)