Roma must put the derby defeat behind them and look to Eldor Shomurodov and Carles Perez in this Europa Conference League trip to Zorya Luhansk.
It kicks off in Ukraine at 17.45 UK time (16.45 GMT).
The Giallorossi opened their Europa Conference League campaign with a 5-1 win over CSKA Sofia, while Zorya were beaten 3-1 by Bodo/Glimt.
Confidence took a hit in recent weeks, with Serie A defeats to Hellas Verona and their arch-rivals Lazio.
Lorenzo Pellegrini was suspended for the derby and returns here, with Perez, Shomurodov and Stephan El Shaarawy, as Mourinho rotates his squad.
Zorya: Matsapura; Khomchenovskyy, Cvek, Imerekov, Favorov; Nazaryna, Buletsa, Kochergin; Sayyadmanesh, Gromov, Kabaiev
Zorya bench: Zhylkin, Lunov, Zahedi, Gladkyy, Owusu, Cristian, Snurnitsyn, Alefirenko
Roma: Rui Patricio; Ibanez, Kumbulla, Smalling, Calafiori; Darboe, Cristante; Carles Perez, Pellegrini, El Shaarawy; Shomurodov
Roma bench: Fuzato, Vina, Villar, Abraham, Reynolds, Mayoral, Zaniolo, Mancini, Diawara, Bova, Zalewski, Mkhitaryan
Ref: Godinho (POR)