Roma look to Nicolò Zaniolo, Stephan El Shaarawy and Tammy Abraham in their must-win Europa Conference League game with Zorya Luhansk.
It kicks off at the Stadio Olimpico in Rome at 20.00 GMT.
The Giallorossi fell to second place in this group after picking up just one point from two games against Bodo/Glimt, including the humiliating 6-1 defeat in Norway.
Jose Mourinho is forced into some changes, as Bryan Cristante and Gonzalo Villar still have COVID, while Lorenzo Pellegrini needs to rest.
Matias Vina and Riccardo Calafiori are still carrying knocks, so it’s a three-man defence again with Chris Smalling making his return from the start.
Zaniolo was dropped for the weekend Serie A win away to Genoa, but is given the chance to shine here with Henrikh Mkhitaryan, Stephan El Shaarawy and Tammy Abraham.
Roma: Rui Patricio; Mancini, Smalling, Kumbulla; Karsdorp, Veretout, Mkhitaryan, El Shaarawy; Perez, Zaniolo; Abraham
Roma bench: Fuzato, Ibanez, Pellegrini, Shomurodov, Reynolds, Mayoral, Diawara, Bove, Darboe, Missori, Zalewski, Tripi
Zorya: Matsapura; Favorov, Vernydub, Imerekov, Juninho; Sayyadamanesh, Buletsa, Cvek, Kabaiev; Gromov, Zahedi
Zorya bench: Saputin, Zhylkin, Khomchenovskyy, Gladkyy, Nazaryna, Owusu, Cristian, Snurnitsyn, Alefirenko