Jose Mourinho and Roma want revenge on Bodo/Glimt for the 6-1 humiliation, so keep squad rotation to a minimum this time against the Norwegians.
It kicks off at the Stadio Olimpico at 20.00 GMT.
The Giallorossi are still smarting from the heavy 6-1 defeat in Norway, which prompted Mourinho to say he only had 13 players in his squad, freezing out Borja Mayoral, Amadou Diawara, Gonzalo Villar and Bryan Reynolds.
They are all recalled for the first time, but still only on the bench, while Lorenzo Pellegrini and Matias Vina are injured.
Stephan El Shaarawy joins Henrikh Mkhitaryan and Nicolò Zaniolo to support Tammy Abraham with almost a full-strength squad.
The difference is Bryan Cristante drops into centre-back, moving Roger Ibanez to left-back.
Bodo/Glimt see no reason to change the side that won 6-1, with Solbakken, Botheim and Pellegrino upfront.
They are currently top of the Europa Conference League group on seven points, followed by Roma on six and Zorya Luhansk on three.
Roma: Rui Patricio; Karsdorp, Mancini, Cristante, Ibanez; Darboe, Veretout; Zaniolo, Mkhitaryan, El Shaarawy; Abraham
Roma bench: Fuzato, Villar, Carles Perez, Calafiori, Shomurodov, Reynolds, Mayoral, Kumbulla, Diawara, Bove, Missori, Zalewski
Bodo/Glimt: Haikin; Sampsted, Moe, Lode, Bjorkan; Fet, Hagen, Konradsen; Solbakken, Botheim, Pellegrino
Bodo/Glimt bench: Smits, Holbraten, Berg, Vetlesen, Kongsro, Moberg, Selvag Nordas, Kvile, Pernambuco, Mugisha, Koomson
Ref: Papapetrou (GRE)