Fiorentina need to better the result of Istanbul Basaksehir to secure top spot in their Conference League group with this trip to RFS Riga.
It kicks off in Latvia at 15.30 GMT.
Both the Viola and Turkish side have already secured qualification for the next phase of the competition, but are currently joint leaders, separated only by head-to-head record.
That means if Fiorentina are to win the group and avoid a play-off, they need to get a better result than Basaksehir do against Hearts.
Vincenzo Italiano’s men are also out for revenge, having wasted so many chances in the 1-1 draw at the Stadio Franchi with RFS.
Riccardo Sottil, Nico Gonzalez and Gaetano Castrovilli are still out injured, while Arthur Cabral is chosen to lead the attack.
RFS: Steinbors; Dubra, Stuglis, Lipuscek; Vlalukin, Zjuzins, Saric, Maksimenko; Simkovic, Ilic, Rakels
Fiorentina: Terracciano; Venuti, Martinez-Quarta, Igor, Terzic; Bonaventura, Mandragora, Barak; Ikone, Cabral, Saponara