Roma rotate the squad with Borja Mayoral and Stephan El Shaarawy as they hope to maintain a perfect Europa Conference League record in this trip to Bodo/Glimt.
It kicks off in Norway at 17.45 UK time (16.45 GMT).
The Giallorossi have won all their European fixtures so far this season, including the preliminary rounds, and can book qualification this evening.
Jose Mourinho rotates the squad, giving rare opportunities to Carles Perez, Gonzalo Villar, El Shaarawy and Mayoral.
Even Bryan Reynolds gets a run-out, although he is widely expected to leave Roma in January.
Norwegians Bodo/Glimt are in second place on four points, having beaten Zorya Luhansk 3-1 here and drew 0-0 away to CSKA Sofia.
Bodo/Glimt: Haikin; Sampsted, Moe, Lode, Bjorkan; Brustad Fet, Berg, Konradsen; Solbakken, Botheim, Pellegrino
Bodo/Glimt bench: Smits, Holbraten, Vetlesen, Kongsro, Moberg, Hagen, Selvag Nordas, Kvile, Pernambuco, Mugisha, Koomson
Roma: Rui Patricio; Reynolds, Ibanez, Kumbulla, Calafiori; Diawara, Villar, Darboe; Carles Perez, El Shaarawy; Mayoral
Roma bench: Fuzato, Cristante, Vina, Pellegrini, Abraham, Shomurodov, Veretout, Mancini, Bove, Zalewski, Tripi, Mkhitaryan
Ref: Palabiyik (TUR)