Roma rely on Tammy Abraham, Nicolò Zaniolo and Sergio Oliveira in the Europa Conference League Round of 16 visit to Vitesse.
The first leg kicks off in Arnhem at 17.45 GMT.
As with all UEFA competitions this season, the away goals rule has been scrapped.
The Giallorossi topped their group and therefore skipped the play-offs last month.
Jose Mourinho has practically a full squad at his disposal and is not rotating, so Zaniolo and Abraham lead the way with Henrikh Mkhitaryan, who is suspended for this weekend in Serie A.
Rick Karsdorp does not get the nod against his former club, so Ainsley Maitland-Niles starts, with Matias Vina replacing not fully fit Nicola Zalewski and Sergio Oliveira returning from injury.
Vitesse have Adrian Grbic back after he missed the most recent Eredivisie game through suspension.
That match against Sparta Rotterdam had to be suspended after a pitch invasion and clashes between fans.
Lois Openda is on fine form with 11 goals in 22 competitive matches this season.
The following players are one yellow card away from suspension for the second leg: Bazoer, Buitink, Doekhi, Oroz, Tronstad, Wittek, Mancini, Kumbulla.
Vitesse: Houwen; Oroz, Rasmussen, Doekhi, Wittek; Dasa, Tronstad, Dmgjoni; Grbic, Openda, Bero
Roma: Rui Patricio; Mancini, Kumbulla, Ibanez; Maitland-Niles, Sergio Oliveira, Veretout, Vina; Mkhitaryan; Zaniolo, Abraham
Ref: Raczkowski (POL)