Roma are forced into changes in defence and midfield, but Tammy Abraham is partnered by Nicolò Zaniolo in this Conference League Round of 16 against Vitesse.
The first leg ended 1-0 for the Giallorossi in Arnhem, so they have a positive result to fall back on, although the away goals rule has been abolished for this season.
The second leg kicks off at the Stadio Olimpico at 20.00 GMT, you can follow all the build-up and action as it happens from this game and Bayer Leverkusen-Atalanta on the LIVEBLOG.
Europa and Conference Liveblog: Bayer Leverkusen-Atalanta and Roma-Vitesse
Gianluca Mancini and Sergio Oliveira are suspended, with Leonardo Spinazzola the only remaining injury absentee.
It means Chris Smalling and Lorenzo Pellegrini step in, while Ainsley Maitland-Niles and Matias Vina take the wide roles.
Despite the fact Roma play arch-rivals Lazio in Serie A on Sunday, Jose Mourinho does not rotate the squad, starting Abraham and Zaniolo upfront.
Vitesse have to do without injured Matus Bero and suspended Alois Dominik Oroz.
Lois Openda is the one to watch upfront, having scored 16 goals in 36 competitive games this season.
Roma: Rui Patricio; Ibanez, Smalling, Kumbulla; Maitland-Niles, Veretout, Mkhitaryan, Vina; Pellegrini; Zaniolo, Abraham
Vitesse: Houwen; Dasa, Doekhi, Rasmussen, Wittek; Tronstad, Bazoer, Domgjoni; Huisman; Grbic, Openda
Ref: Petrescu (ROU)