Fiorentina look to Arthur Cabral and Riccardo Saponara in this difficult Conference League trip to Stefano Okaka’s Istanbul Basaksehir.
It kicks off in Turkey at 20.00 UK time (19.00 GMT), in a stadium named after former Fiorentina coach Fatih Terim.
Vincenzo Italiano is increasingly frustrated with his team’s inability to convert scoring opportunities, managing just three goals in their last seven competitive matches.
They were held 1-1 at home in the Conference League by RFS Riga and beaten 2-1 in Serie A at the weekend by Bologna.
Italiano also has to rotate the squad, so brings in Arthur Cabral, Riccardo Saponara and Jonathan Ikone.
Dodo, Nikola Milenkovic, Alfred Duncan, Nico Gonzalez and Gaetano Castrovilli are all carrying injuries.
Istanbul Basaksehir crushed Hearts 4-0 in their opening Conference League game and are filled with familiar faces, including Italy international Stefano Okaka and ex-Lazio midfielder Lucas Biglia.
Their coach is former Inter man Emre Belozoglu.
Istanbul Basaksehir: Muhammed Sengezer; Caicara, Ndiashimiye, Touba, Hasan Ali Kaldirim; Aleksic, Biglia, Berkay Ozcan; Serdar Gurler, Okaka, Chouiar
Fiorentina: Gollini; Venuti, Martinez Quarta, Igor, Terzic; Bonaventura, Amrabat, Maleh; Ikone, Cabral, Saponara