Fiorentina reached the Conference League Final last season and hope to go even better, starting with a trip to KRC Genk with Lucas Beltran and Nico Gonzalez.
It kicks off in Belgium at 17.45 UK time (16.45 GMT).
The Viola are coming off a 3-2 victory against Atalanta and already had to get through the preliminary round with Rapid Vienna.
Giacomo Bonaventura is out with bruised ribs, while Yerry Mina, Gaetano Castrovilli and Jonathan Ikone are also sidelined.
Genk dropped into the Conference League after losing the Champions League play-off with Servette and then the Europa League preliminary round with Olympiacos.
This group includes Ferencvaros and Cucaricki.
Genk: Vandervoodt; Munoz, Sadick, McKenzie, Arteaga; El Khannouss, Galarza, Heynen, Oyen; Zeqiri, Fadera
Fiorentina: Christensen; Kayode, Milenkovic, Ranieri, Biraghi; Duncan, Mandragora, Arthur; Nico Gonzalez, Beltran, Sottil
Ref: Frappart (FRA)
|7'||Luca Ranieri |
(Assist: Cristiano Biraghi)
|23'||Luca Ranieri |
(Assist: Nikola Milenkovic)
(Assist: Bilal El Khannouss)