Fiorentina begin their Conference League campaign by hosting Latvians RFS Riga with Arthur Cabral, Antonin Barak and Christian Kouame.
It kicks off at the Stadio Franchi at 17.45 UK time (16.45 GMT).
The Viola qualified for this competition by finishing seventh in Serie A last season, then eliminating FC Twente in the play-offs, 2-1 on aggregate.
This group is completed by Hearts and Istanbul Basaksehir.
Fiorentina ended a run of four competitive games without a single goal scored with their 1-1 draw against Juventus on Saturday.
Giacomo Bonaventura returns after compassionate leave, with Arthur Cabral, Christian Kouame and Jonathan Ikone upfront.
Nikola Milenkovic, Alfred Duncan and Gaetano Castrovilli are injured, with Igor suspended.
Fiorentina: Gollini; Dodo, Martinez-Quarta, Ranieri, Biraghi; Bonaventura, Barak, Amrabat; Kouame, Cabral, Ikone
RFS Riga: Steinbors; Jagodinskis, Stuglis, Lipuscek; Sorokins, Panic, Saric, Mares; Simkovic, Ilic, Emerson Santana
3 points are a must