Fiorentina could guarantee passage to the Conference League knockouts with a win against group leaders Istanbul Basaksehir, as Luka Jovic, Riccardo Saponara and Christian Kouame complete the trident attack.
It kicks off at the Stadio Artemio Franchi at 17.45 UK time (16.45 GMT).
The Viola are still smarting after the dramatic and controversial 4-3 home defeat to Inter at the weekend.
Their Conference League position is stronger, sitting in second place three points behind Istanbul Basaksehir after twice thrashing Hearts.
Nico Gonzalez, Riccardo Sottil and Gaetano Castrovilli are injured, but Jovic is back in the starting XI after his volley against Inter.
Istanbul Basaksehir won 3-0 when these sides met on September 15, but Ahmed Touba and Mesut Ozil are injured.
Alexandru Epureanu, Francis Nzaba, Okechukwu Azubuike, Sekou Tidiany Bangoura and Philippe Keny are not eligible for the Conference League.
They have some very familiar faces, including ex-Lazio midfielder Lucas Biglia, Milan defender Leo Duarte and former Roma striker Stefano Okaka.
Fiorentina: Gollini; Dodo, Milenkovic, Igor, Terzic; Barak, Amrabat, Mandragora; Kouame, Jovic, Saponara
Istanbul Basaksehir: Sengezer; Junior Caicara, Ndayishimiye, Duarte, Lima; Aleksic, Biglia, Mahmut Tekdemir; Deniz Turuc, Okaka, Chouiar
Ref: Lindhout (NED)