Lazio are decimated for the Conference League play-off in Romania, but hope Ciro Immobile and Felipe Anderson can protect the first leg lead against CFR Cluj.
It kicks off at the Stadionul Constantin Radulescu at 17.45 GMT.
The first leg ended 1-0 for the Biancocelesti thanks to an Immobile volley, despite Patric being harshly sent off just 15 minutes in.
Because of that card, Patric is suspended, with Alessio Romagnoli, Sergej Milinkovic-Savic, Mattia Zaccagni, Pedro and Stefan Radu injured.
Luis Alberto pulls the midfield strings and Mario Gila joins a reshuffled defence.
Cluj have former Udinese goalkeeper Simone Scuffet, while Ciprian Deac and Rangelo Janga are their top scorers for this season with six goals apiece.
Cluj: Scuffet; Manea, Kolinger, Burca, Camora; Deac, Muhar, Cvek, Krasniqi; Malele, Janga
Lazio: Maximiano; Lazzari, Gila, Casale, Hysaj; Basic, Cataldi, Luis Alberto; Romero, Immobile, Felipe Anderson
Player statistic
| 14' |  |
Nicolò Casale | ||
| Karlo Muhar | |
36' | ||
| 37' | |
Ciro Immobile |
| Ciprian Deac | |
54' | ||
| Lovro Cvek | |
59' | ||
| Karlo Muhar |  |
77' |
Match statistic
