Fiorentina begin their Conference League campaign by hosting Welsh side The New Saints with Lucas Beltran, Yacine Adli and Christian Kouame.
It kicks off at the Stadio Artemio Franchi at 20.00 UK time (19.00 GMT).
The Viola have struggled so far under new coach Raffaele Palladino, winning only one game 2-1 against Lazio, but also losing only 3-2 to Atalanta, drawing the other six matches.
Those include the Conference League play-off ties with Puskas, which were only resolved in a penalty shoot-out.
There is vast squad rotation including summer signings Adli and Richardson in midfield, while Beltran takes over upfront from Moise Kean.
Some of that is caused by the bans to Luca Ranieri, Pietro Comuzzo and Lucas Martinez Quarta, while Marin Pongracic is injured.
This is an historic moment for The New Saints, a small club from Wales that lost Champions League preliminary games to Ferencvaros, Europa League to Petrocub and then eliminated Panevezys in the Conference League play-off.
Ryan Astles, Harrison McGahey, Matthew Olosunde and Ash Baker are not fully fit, with Jordan Williams suspended.
Fiorentina vs. The New Saints line-ups
Fiorentina: Terracciano; Kayode, Moreno, Biraghi, Parisi; Mandragora, Adli; Ikoné, Kouame, Sottil; Beltran
The New Saints: C Roberts; Daniels, D Davies, Bodenham, Redmond; Clark, Smith, D Williams; Bradley, Wilson, Holden
Ref: Gishamer (AUT)
Match statistic
