There are reports Dejan Kulusevski will be chosen to lead the Juventus attack, sending Federico Chiesa to the bench, while Arturo Vidal is a potential starter for Inter.
It kicks off at San Siro at 19.45 UK time (18.45 GMT).
Max Allegri is on a run of 1-0 results in both Serie A and the Champions League, so has decided to keep things tight and strike on the counter.
Paulo Dybala is back in the squad after a muscular problem, but Moise Kean and Adrien Rabiot are unavailable.
According to the latest reports from Sky Sport Italia, Kulusevski will be picked to partner Alvaro Morata in a 3-5-2 formation rather than Chiesa.
The Italy international centre-back pairing of Leonardo Bonucci and Giorgio Chiellini should also send Matthijs de Ligt to the bench.
As for Inter, Alessandro Bastoni is expected to return in defence after he was rested in the Champions League midweek against Sheriff.
The big doubt is in midfield, where Hakan Calhanoglu is not 100 per cent fit, so Arturo Vidal could face his former club.
Probable line-ups
Inter (3-5-2): Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro Martinez
Juventus (3-5-2): Szczesny; Danilo, Bonucci, Chiellini; Cuadrado, Bernardeschi, Locatelli, McKennie, Alex Sandro; Kulusevski, Morata