Lautaro Martinez makes a remarkable recovery to start with Marcus Thuram for Inter, while Barcelona have Robert Lewandowski on the bench, so Lamine Yamal and Raphina play in the Champions League semi-final.
It kicks off at San Siro at 20.00 UK time (19.00 GMT, 21.00 CET).
You can follow all the build-up and action as it happens on the Liveblog.
The first leg was a 3-3 thriller, so with no away goals rule, it is winner takes all after 90 minutes, extra time or even penalties.
Inter had worried they would be without their captain and star striker after he limped off at half-time last week, but Lautaro Martinez has made a lightning fast recovery to start with Thuram.
Benjamin Pavard is still not fully fit with an ankle sprain, having missed the first leg, so Yann Bisseck takes over in defence.
Despite suggestions otherwise, Federico Dimarco and Denzel Dumfries are confirmed as the wing-backs.
Barcelona forced into changes with Inter
Barcelona lost Jules Koundé to a hamstring issue, so he is out of action along with Alejandro Balde, Marc Bernal, Pablo Torre and Marc Casadó.
After missing the first showdown, Lewandowski is available on the bench, but hasn’t played since limping off with a hamstring strain in the 4-3 win over Celta Vigo on April 19.
The big danger from the first match was Lamine Yamal, who tortured Dimarco down Barcelona’s right flank.
It remains to be seen if he’ll be just as influential here, starting with Dani Olmo and Raphinha behind Ferran Torres.
Although Marc Andre ter Stegen made his return to the field at the weekend, it is ex-Juventus goalkeeper Wojciech Szczesny who is confirmed.
The big problem is in defence, where in the absence of Koundé, coach Hansi Flick brings in Eric Garcia.
Inter vs. Barcelona official line-ups (3-3 agg)
Inter: Sommer; Bisseck, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Thuram
Inter bench: Di Gennaro, J Martinez, De Vrij, Zielinski, Arnautovic, Frattesi, Asllani, Carlos Augusto, Darmian, Re Cecconi, Zalewski, Taremi
Barcelona: Szczesny; Eric García, Cubarsì, Iñigo Martinez, Gerard Martin; Pedri, De Jong, Dani Olmo; Lamine Yamal, Ferran Torres, Raphinha
Barcelona bench: Inaki Pena, Astralaga, Ronald Araujo, Gavi, Lewandowski, Ansu Fati, Christensen, Fermin Lopez, Pau Victor, Fort, Farré, Darvich
Ref: Marciniak (POL)
Player statistic
| Lautaro Martínez (Assist: Denzel Dumfries) |
 |
21' | ||
| Hakan Calhanoglu |  |
36' | ||
| Hakan Calhanoglu |  |
45' |
| 51' | |
Iñigo Martínez | ||
| 54' | |
Eric García (Assist: Gerard Martin) | ||
| 60' | |
Dani Olmo (Assist: Gerard Martin) | ||
| Henrikh Mkhitaryan | |
68' | ||
| 87' | |
Raphinha | ||
| Francesco Acerbi (Assist: Denzel Dumfries) |
|
90+3' | ||
| Francesco Acerbi | |
90+4' |
| Carlos Augusto | |
91' | ||
| Davide Frattesi (Assist: Mehdi Taremi) |
|
99' | ||
| Alessandro Bastoni | |
118' |
Match statistic
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