André Onana is expected to start in goal for Inter with Edin Dzeko or Joaquin Correa replacing Romelu Lukaku.
It’s a must-win game for the Nerazzurri, who lost the opening Champions League group stage game against Bayern Munich last week.
It kicks off at 17.45 UK time.
Romelu Lukaku is the only injured player for the Serie A giants who snatched a late 1-0 win over Torino on Saturday.
Onana is expected to make his second appearance with the Nerazzurri. Denzel Dumfries is favourite over Matteo Darmian on the right, and so is Correa up front.
The Argentinean should partner his compatriot Lautaro Martinez up front.
El Toro has only scored two Champions League goals since 2020-21 and has the lowest conversion rate among players with at least 30 shots (4.2% two goals with 48 shots).
The Nerazzurri won the last away game in Europe last season (against Liverpool) and the last time they won two away games in a row in the Champions League was in 2011.
They haven’t lost the opening two games in the competition since 2006-07 under Roberto Mancini.
UPDATE: Lautaro Martinez is expected to go to the bench with Francesco Acerbi making his debut as a starter in place of Stefan de Vrij (read more).
Viktoria Plzen-Inter: probable line-ups
Viktoria Plzen (4-2-3-1): Stanek; Havel, Hejda, Pernica, Jemelka; Kalvach, Bucha; Mosquera, Vikanova, Sykora; Chory.
Inter (3-5-2): Onana; Skriniar, Acerbi, Bastoni; Dumfries, Barella, Brozovic, Mkhitaryan, Gosens; Dzeko, Correa.