Inter are expected to start with Edin Dzeko and Lautaro Martinez when the Nerazzurri fight Real Madrid for the top spot in Group D.
Carlo Ancelotti’s men secured a narrow win at San Siro last time, but are without France international Karim Benzema ahead of the return leg.
Serbian striker Luka Jovic is expected to play in his absence and the former Eintracht Frankfurt player arrives from a goal and an assist in the last league match.
Rodrygo and Vinicius are expected to take place next to Jovic, while Casemiro, Toni Kroos and Luka Modric should start in the midfield trident.
Simone Inzaghi should have Stefan de Vrij back, but the Dutch defender won’t start in the Spanish capital.
Denzel Dumfries and Ivan Perisic should play out wide, with Nicolò Barella, Marcelo Brozovic and Hakan Calhanoglu in the middle.
Joaquin Correa is out with a flexor problem, meaning Dzeko and Lautaro are ready to start at the Santiago Bernabeu.
Probable line-ups: Real Madrid vs. Inter
Real Madrid (4-3-3): Courtois; Carvajal, Militao, Alaba, Mendy; Modric, Casemiro, Kroos; Rodrygo, Jovic, Vinicius
Inter (3-5-2): Handanovic; D’Ambrosio, Skriniar, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro