Carlo Ancelotti’s men secured a narrow win at San Siro last time, but are without France international Karim Benzema ahead of the return leg.
Serbian striker Luka Jovic is expected to play in his absence and the former Eintracht Frankfurt player arrives from a goal and an assist in the last league match.
Simone Inzaghi should have Stefan de Vrij back, but the Dutch defender won’t start in the Spanish capital.
Joaquin Correa is out with a flexor problem, meaning Dzeko and Lautaro are ready to start at the Santiago Bernabeu.
Probable line-ups: Real Madrid vs. Inter
Inter (3-5-2): Handanovic; D’Ambrosio, Skriniar, Bastoni; Dumfries, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro