Napoli host Carlo Ancelotti’s Real Madrid at the Stadio Maradona tonight with Rudi Garcia relying on his brightest stars, including Victor Osimhen and Khvicha Kvaratskhelia.
It kicks off at 20:00 BST.
Both Napoli and Madrid won the opening group-stage game two weeks ago and are the Group C favourites to qualify for the Round of 16.
The Partenopei must do without the injured Pierluigi Gollini, Amir Rrahmani and Juan Jesus.
This means Brazilian defender Natan will start his first-ever Champions League game. Mathias Olivera is favourite over Mario Rui at left-back, while Matteo Politano will join Osimhen and Kvaratskhelia in attack.
The Nigerian striker partially rested against Lecce on Saturday, but was introduced in the second half scoring one of Napoli’s goals in a 4-0 win at the Via Del Mare.
Real Madrid’s Thibaut Courtois, Eder Militao, Arda Guler and David Alaba are injured, but Ancelotti can still rely on Jude Bellingham, Rodrygo and Vini Jr. in attack.
Napoli vs Real Madrid – probable line-ups
Napoli (4-3-3): Meret; Di Lorenzo, Ostigard, Natan, Olivera; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia.
Real Madrid (4-3-1-2): Kepa; Carvajal, Rudiger, Nacho, Camavinga; Valverde, Tchouameni, Modric; Bellingham; Rodrygo, Vinicius.
Madrid will win 3