Inter go all-out attack in Moldova against Sheriff, starting Lautaro Martinez, Edin Dzeko and Arturo Vidal to beat the surprise Champions League group leaders.
It kicks off in Tiraspol at 20.00 GMT.
Nothing has gone to plan so far in Group D, because Sheriff won their opening two games against Shakhtar Donetsk and Real Madrid, then lost 3-1 at San Siro.
It means Sheriff and Real Madrid are joint top on six points, followed by Inter on four.
Simone Inzaghi has the Milan Derby coming up in Serie A this weekend, but still fields practically his best XI.
Vidal steps in for Hakan Calhanoglu, while Lautaro Martinez and Edin Dzeko lead the attack.
Sheriff already caused a few upsets in this debut Champions League campaign and are eager to add another scalp.
Sheriff: Athanasiadis; Costanza, Arboleda, Dulanto, Cristiano; Addo, Thill; Traorè, Kolovos, Castaneda; Yakhshiboev
Sheriff bench: Celeadnic, Pascenco, Radeljic, Belousov, Julien, Cojocari, Bruno, Cojocaru,
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Vidal, Dimarco; Dzeko, Lautaro Martinez
Inter bench: Radu, Dumfries, Gagliardini, Alexis Sanchez, Vecino, Kolarov, Sensi, Ranocchia, Perisic, Correa, Calhanoglu, D’Ambrosio
Ref: Zwayer (GER)