Milan rely on Zlatan Ibrahimovic, Brahim Diaz and Junior Messias, as they must beat Mohamed Salah’s Liverpool and hope Atletico Madrid draw with FC Porto to continue in the Champions League.
It kicks off at 20.00 GMT at the Stadio Giuseppe Meazza, also known as San Siro.
Champions League Liveblog: Real Madrid-Inter and Milan-Liverpool
The Rossoneri managed just one point from the opening four group games, but could still reach the Round of 16.
They need to win tonight and hope FC Porto draw with Atletico Madrid in the other match.
Injuries continue to pile up for Stefano Pioli, who is missing Rafael Leao, Simon Kjaer, Olivier Giroud, Ante Rebic and Davide Calabria, but Mike Maignan made his comeback in goal several weeks ahead of schedule after wrist surgery.
Ibrahimovic is therefore the only real choice to lead the attack, with Rade Krunic stepping in to join Messias and Brahim Diaz.
Theo Hernandez and Fikayo Tomori have to be careful, as they are one yellow card away from suspension.
Liverpool have already qualified top of this group, so can rotate to their heart’s content at San Siro after fighting back from 2-0 down to win 3-2 at Anfield.
Virgil van Dijk, Roberto Firmino, Curtis Jones and Harvey Elliott are injured, while James Milner sits out a ban.
Former Roma and Fiorentina striker Salah is in Jurgen Klopp’s trident attack with Divock Origi and Sadio Mané.
It’s never a normal game between these clubs, as Liverpool famously came back from 3-0 down to win the 2005 Champions League Final on penalties, then Milan took revenge in the 2007 Final.
Milan: Maignan; Kalulu, Tomori, Romagnoli, Theo Hernandez; Tonali, Kessie; Messias, Brahim Diaz, Krunic; Ibrahimovic
Milan bench: Tatarusanu, Jungdal, Bennacer, Ballo-Toure, Florenzi, Maldini, Bakayoko, Gabbia, Saelemaekers
Liverpool: Alisson; N Williams, Konaté, Phillips, Tsimikas; Oxlade-Chamberlain, Morton, Minamino; Salah, Origi, Mané
Liverpool bench: Kelleher, Davies, Fabinho, Keita, Gomez, Robertson, Matip, Dixon-Bonner, Alexander-Arnold, Norris, Woltman, Bradley
Ref: Makkelie (NED)
So everything is in milans hands, home pitch, local tifosi support…and if we think li erpool attack is scary but we look at midfield and defence and we see there is everything in milan hands today, lets go Milan!