Juventus have Federico Chiesa back with Paulo Dybala and Alvaro Morata, as a draw against Zenit would be enough to book Champions League passage to the Round of 16.
It kicks off at the Allianz Juventus Stadium at 20.00 GMT.
Champions League liveblog: Atalanta vs. Man United and Juventus vs. Zenit
The Bianconeri might be in crisis mode in Serie A with one point from the last three rounds, but their Champions League campaign has been perfect with three wins out of three and all clean sheets.
It means a draw here would be sufficient to book their place in the Round of 16.
Moise Kean, Aaron Ramsey and Mattia De Sciglio are out injured, but Chiesa returns from a muscular issue and starts in wide midfield, supporting Dybala and Morata.
It’s an important comeback, considering Chiesa has five goals in his last six Champions League games.
Matthijs de Ligt also steps back in after a knock to bolster the defence, while Weston McKennie is preferred to Rodrigo Bentancur in midfield.
Zenit are missing Magomed Ozdoev, while Malcom, Douglas Santos, Danil Krugovoi and Daler Kuzyaev are carrying fitness concerns.
Juventus won 1-0 in St Petersburg last time out with a late Dejan Kulusevski strike.
Juventus: Szczesny; Danilo, Bonucci, De Ligt, Alex Sandro; Chiesa, McKennie, Locatelli, Bernardeschi; Dybala, Morata
Juventus bench: Pinsoglio, Perin, Chiellini, Arthur, Cuadrado, Rugani, Rabiot, Bentancur, Kulusevski
Zenit: Kritsyuk; Chistiakov, Lovren, Rakitskyy; Sutormin, Barrios, Wendel, Karavaev; Mostovoy, Claudinho, Azmoun
Zenit bench: M Kerzhakov, Byazrov, Krugovoi, Malcom, Erokhin, Dzyba, Kravstov, Kuznetsov, Khotulev
Ref: Hernandez (ESP)
On to the Knockout Round with 2 matches to spare.