Juventus are forced to completely revamp their attack amid an injury crisis as they host Champions League holders Chelsea, including Jorginho and Romelu Lukaku.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 UK time (19.00 GMT).
Max Allegri has found life back with the Bianconeri more difficult than expected, partly due to a series of injuries.
Paulo Dybala, Alvaro Morata, Kaio Jorge, Aaron Ramsey and Arthur Melo are all out of action, with Adrien Rabiot not 100 per cent fit either, but still starting.
Allegri has to transform his side to fill the gaps, with Federico Chiesa and Juan Cuadrado flanking False 9 Federico Bernardeschi.
The only available striker in the squad is Moise Kean, yet he is initially left on the bench.
Chelsea won the Champions League last season with Jorginho in midfield and the Italy international is back to face his old foes Juventus.
So is Romelu Lukaku, who won the Scudetto last term with Inter and returns to the Peninsula wearing the Blue jersey.
The big loss for Thomas Tuchel is midfielder N’Golo Kante, who has tested positive for COVID-19 and therefore hasn’t made the trip, along with Reece James, while Mason Mount and Christian Pulisic are carrying knocks.
Other former Serie A players featuring are Mateo Kovacic, Thiago Silva and Antonio Rudiger.
Juventus: Szczesny; Danilo, Bonucci, De Ligt, Alex Sandro; Bentancur, Locatelli, Rabiot; Cuadrado, Bernardeschi, Chiesa
Juventus bench: Pinsoglio, Perin, De Sciglio, Chiellini, McKennie, Kean, Rugani, Kulusevski
Chelsea: Mendy; Christensen, Thiago Silva, Rudiger; Azpilicueta, Jorginho, Kovacic, Alonso; Ziyech, Havertz; Lukaku
Chelsea bench: Kepa, Bettinelli, Werner, Loftus-Cheek, Chalobah, Niguez Esclapez, Barkley, Hudson-Odoi, Chilwell, Sarr
Ref: Manzano (ESP)