Inter have Alessandro Bastoni back in defence, starting Lautaro Martinez and Edin Dzeko for their Champions League showdown with Carlo Ancelotti’s Real Madrid.
It kicks off at San Siro at 20.00 UK time (19.00 GMT).
Champions League Liveblog: Inter-Real Madrid and Liverpool-Milan
Inter have started the season strong under new coach Simone Inzaghi, despite losing Romelu Lukaku and Achraf Hakimi over the summer.
They did drop points for the first time at the weekend with a 2-2 draw against Sampdoria in Serie A, but still have seven points from three rounds.
Stefano Sensi is out of action, but Bastoni returns after a slight muscular issue.
Matteo Darmian gets the nod rather than Denzel Dumfries on the right, while Hakan Calhanoglu supports Dzeko and Lautaro Martinez.
Real Madrid is missing Marcelo, Toni Kroos, Gareth Bale, Dani Ceballos and Ferland Mendy, while Luka Modric and David Alaba are not 100 per cent fit, but start anyway.
Karim Benzema is on spectacular form again, supported by Vinicius and Lucas Vazquez, preferred to Eden Hazard.
It is a special match for former Milan coach Ancelotti, who called San Siro home both as a player and coach.
He returned to Real Madrid for his second stint this summer, after brief spells at Everton and Napoli.
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Darmian, Barella, Brozovic, Calhanoglu, Perisic; Dzeko, Lautaro Martinez
Inter bench: Cordaz, Radu, Dumfries, Gagliardini, Alexis Sanchez, Vecino, Kolarov, Ranocchia, Correa, Vidal, Dimarco, D’Ambrosio
Real Madrid: Courtois; Carvajal, Militao, Nacho, Alaba; Valverde, Casemiro, Modric; Lucas Vazquez, Benzema, Vinicius
Real Madrid bench: Lunin, Toni Fuidias, Vallejo, Hazard, Asensio, Jovic, Rodrygo, Isco, Mariano, Camavinga, Bianco, Miguel
Ref: Siebert (GER)