Atalanta bring in Merih Demiral with Duvan Zapata, Ruslan Malinovskyi and Matteo Pessina against Swiss side Young Boys in an historic Champions League match.
It kicks off at the Gewiss Stadium at 17.45 UK time (16.45 GMT).
This is the first time ever that Atalanta have been able to play a Champions League fixture in front of their home fans in Bergamo, as when this stadium was given the all-clear, the pandemic had already begun.
It’s only 50 per cent capacity, but still a memorable moment for this club in their third consecutive Champions League campaign.
Luis Muriel is back on the bench after his thigh injury, so only Hans Hateboer and Jose Luis Palomino are still on the treatment table.
Demiral comes in for defence, with Davide Zappacosta and Robin Gosens on the wings, supporting Malinovskyi, Pessina and Duvan Zapata.
Young Boys fought back to beat 10-man Manchester United in their opening game and are therefore top of this group.
Christian Fassnacht has been ruled out after a nasty clash of heads at the weekend, so Meschack Elia comes in to support striker Jordan Pefok Siebatcheu.
Also injured are Jean-Pierre Nsame, Joel Monteiro, Cedric Zesiger, Fabian Lustenberger, Nico Maier and Esteban Petignat.
Atalanta: Musso; Toloi, Demiral, Djimsiti; Zappacosta, De Roon, Freuler, Gosens; Pessina; Malinovskyi, Duvan Zapata
Atalanta bench: Rossi, Sportiello, Maehle, Koopmeiners, Muriel, Pezzella, Scalvini, Miranchuk, Lovato, Ilicic, Pasalic, Piccoli
Young Boys: Von Ballmoos; Hefti, Camara, Lauper, Garcia; Martins Pereira, Sierro; Elia, Aebischer, Ngamaleu; Siebatcheu
Young Boys bench: Laidani, Faivre, Spielmann, Kanga, Sulejmani, Jankewitz, Burgy, Mambimbi, Maceiras, Lefort, Rieder
Ref: Brych (GER)