Atalanta need a victory against Villarreal to reach the Champions League Round of 16, so they look to Duvan Zapata, Josip Ilicic and Matteo Pessina against Gerard Moreno and Raul Albiol under the snow.
It kicks off at the Gewiss Stadium in Bergamo at 20.00 GMT and the snow is intensifying as the evening goes on.
Champions League Liveblog: Juventus-Malmo, Atalanta-Villarreal
La Dea could reach the knockout stage of the competition for the third time in as many participations, but only a win will do here.
Robin Gosens is out until the New Year, while Davide Zappacosta also has a slight issue, so Hans Hateboer takes the right flank.
Duvan Zapata is supported by Josip Ilicic and Matteo Pessina, although it was expected to be Ruslan Malinovskyi and Mario Pasalic.
They drew 1-1 with Villarreal away from home and the Spaniards are without suspended Yeremi Pino and injured Francis Coquelin.
Arnaut Danjuma partners Gerard Moreno upfront, while ex-Napoli defender Albiol also starts.
There is also the possibility that Atalanta could go out of Europe completely, if they lose tonight and Young Boys beat Manchester United.
Any other result and La Dea will finish third, dropping into the Europa League.
It is snowing heavily in Bergamo and red lines have been painted on ahead of a pitch inspection.
Atalanta: Musso; Toloi, Demiral, Palomino; Hateboer, De Roon, Freuler, Maehle; Pessina; Ilicic, Duvan Zapata
Atalanta bench: Rossi, Sportiello, Koopmeiners, Muriel, Pezzella, Malinovskyi, Djimsiti, Miranchuk, Lovato, Zappacosta, Pasalic, Piccoli
Villarreal: Rulli; Foyth, Albiol, Pau Torres, Estupinian; Moi Gomez, Capouè, Parejo, Alberto Moreno; Gerard Moreno, Danjuma
Villarreal bench: Asenjo, Jorgensen, Mario Gaspar, Alcacer, Iborra, Chukwueze, Trigeueros, Dia, Raba, Pena, Mandi, Pedraza
Ref: Taylor (ENG)