Inter are forced to ring the changes in the Champions League trip to Young Boys, as Davide Frattesi, Nicolò Barella and Mehdi Taremi lead the way.
It kicks off at the Stadion Wankdorf in Bern at 20.00 UK time (19.00 GMT).
The Nerazzurri have had a strong start in Europe with a 0-0 draw away to Manchester City and 4-0 demolition of Crvena Zvezda at San Siro.
Since the painful 2-1 loss to Milan, they’ve put together four consecutive victories in all competition.
However, the 1-0 win at Roma on Sunday came at a price, with Hakan Calhanoglu and Francesco Acerbi joining Piotr Zielinski and Kristjan Asllani on the treatment table.
It’s therefore a revamped midfield with Barella as playmaker alongside Frattesi and Henrikh Mkhitaryan, while Taremi and Marko Arnautovic start upfront, resting Lautaro Martinez and Marcus Thuram for this weekend’s Serie A showdown with Juventus.
Young Boys have struggled so far, losing 3-0 at home to Aston Villa and 5-0 away to Barcelona, but they did beat Galatasaray in both legs of the play-offs.
The biggest danger of this fixture could be the artificial turf, which can lead to further injuries and an irregular bounce of the ball.
Miguel Chaiwa, Saidy Janko, Patric Pfeiffer, Facinet Conte and Tanguy Zoukrou are out of action.
Young Boys vs. Inter line-ups
Young Boys: Von Ballmoos; Blum, Lauper, Benito, Hadjam; Lakomy, Ugrinic; Virgiunius, Imeri, Monteiro; Ganvoula
Inter: Sommer; Pavard, De Vrij, Bisseck; Dumfries, Frattesi, Barella, Mkhitaryan, Carlos Augusto; Taremi, Arnautovic
Ref: Oliver (ENG)
