Juventus give Dusan Vlahovic his full Champions League debut with Alvaro Morata and Matthijs de Ligt starting too against Alberto Moreno’s Villarreal.
This is the first leg of the Champions League Round of 16 and kicks off at La Ceramica at 20.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Bianconeri go into this game without some key players, as Paulo Dybala, Giorgio Chiellini, Federico Chiesa, Daniele Rugani and Federico Bernardeschi are out of action.
Leonardo Bonucci and Luca Pellegrini are not at 100 per cent either, so Max Allegri is forced to experiment in defence with Danilo as a centre-back, Mattia De Sciglio and Alex Sandro on the flanks.
January buy Vlahovic starts, which in the case of the Serbian is his full debut in the competition, but Denis Zakaria and Arthur Melo are on the bench.
Villarreal finished runners-up in their group behind Manchester United, eliminating Atalanta from the tournament.
They are forced to do without injured Gerard Moreno, Francis Coquelin and Ruben Peña.
Alberto Moreno, Samu Chukwueze and Arnaut Danjuma therefore complete the trident attack, with Giovani Lo Celso in midfield.
Veteran and former Napoli defender Raul Albiol is tasked with neutralising Vlahovic and Morata.
Both sides have to keep an eye on the bookings, because Juan Cuadrado, Alberto Moreno and Dani Parejo are one yellow card away from suspension.
Villarreal: Rulli; Foyth, Albiol, Pau Torres, Pedraza; Capoue, Lo Celso, Parejo; Alberto Moreno, Chukwueze, Danjuma
Villarreal bench: Asenjo, Jorgensen, Mario Gaspar, Iborra, Estupinan, M Trigueros, Dia, Yeremy, Mandi, Moi Gomez, Serge Aurier
Juventus: Szczesny; De Sciglio, Danilo, De Ligt, Alex Sandro; Cuadrado, Locatelli, McKennie, Rabiot; Morata, Vlahovic
Juventus bench: Pinsoglio, Perin, Arthur, Pellegrini, Kean, Bonucci, Zakaria, Soule