Giovanni Simeone is chosen to lead the Napoli attack with Kvicha Kvaratskhelia and Matteo Politano, knowing a win away to Glasgow Rangers would send them three points clear in this Champions League group.
It kicks off at Ibrox at 20.00 UK time (19.00 GMT).
The Partenopei started the campaign with a thumping 4-1 victory over Liverpool, while Rangers were beaten 4-0 by Ajax.
Last night, Liverpool already beat Ajax 2-1, so both those sides are now on three points.
This game was originally meant to be yesterday, but moved forward 24 hours due to security concerns, as police were already over-stretched by preparations for Queen Elizabeth II’s funeral.
Osimhen, Hirving Lozano and Diego Demme did not make the trip, so Simeone is chosen rather than Giacomo Raspadori to lead the attack with on-form Georgia international Kvaratskhelia.
Napoli also have to keep an eye on Sunday’s Serie A Scudetto showdown with Milan.
Rangers did not play at the weekend, as all fixtures were cancelled in Great Britain following the death of the Queen, so they’ve lost their last two competitive matches by 4-0 scorelines against Celtic and Ajax.
Goalkeeper Jon McLaughlin is injured, so 40-year-old Allan McGregor steps back into the side, with Tom Lawrence, Ben Davies, John Souttar, Filip Helander, Kemar Roofe and Ianis Hagi also out of action.
Rangers: McGregor; Tavernier, Sands, Goldson, Barisic; Lundstram, Jack, S Davis; Arfield, Morelos, Kent
Rangers bench: R McCrorie, Budinauckas, Ridvan Yilmaz, Colak, Matondo, Kamara, Wright, Davies, Sakala, King, Devine, Tillman
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Politano, Simeone, Kvaratskhelia
Napoli bench: Idasiak, Sirigu, Juan Jesus, Elmas, Olivera, Zerbin, Ostigard, Zanoli, Gaetano, Raspadori, Ndombele