Milan hope for their first Champions League points in a trip to FC Porto, with Ciprian Tatarusanu, Olivier Giroud and Rade Krunic starting amid an injury crisis, facing Otavio and Mehdi Taremi.
It kicks off at the Estadio do Dragao at 20.00 UK time (19.00 GMT).
The Rossoneri had a rough start to their Champions League experience, suffering unlucky and at times controversial defeats to Liverpool and Atletico Madrid.
FC Porto haven’t fared much better, drawing 0-0 in Madrid and crushed 5-1 at home by Liverpool.
Milan are decimated by injuries, illness and bans, because Franck Kessie is suspended in the Champions League following his red card against Atletico Madrid.
Theo Hernandez and Brahim Diaz are still COVID-positive, Ante Rebic picked up an ankle problem in the 3-2 comeback win over Hellas Verona, joining Mike Maignan, Junior Messias, Alessandro Florenzi and Alessandro Plizzari on the treatment table.
This is goalkeeper Tatarusanu’s first Champions League appearance since December 2013 for Steaua Bucharest.
Zlatan Ibrahimovic made his comeback at the weekend, but is not ready to start, so Giroud leads the way with Rade Krunic in a new trequartista role.
Porto and their coach, former Inter, Lazio and Parma star Sergio Conceicao, have veteran Pepe and surprisingly start Chancel Mbemba, who had been in doubt.
It is intriguing to see Jesus ‘Tecatito’ Corona, who was one of the Milan transfer targets over the summer, dropped from the starting XI.
Porto: Diogo Costa; Joao Mario, Pepe, Mbemba, Wendell; Uribe, Sergio Oliveira, Otavio, Evanilson; Luis Diaz, Taremi
Porto bench: Marchesin, Marcano, Francisco Conceicao, Pepê, Zaidu, Grujic, Corona, Manafa, Vitinha, Bruno Costa, Toni Martinez, Fabio Vieira
Milan: Tatarusanu; Calabria, Tomori, Kjaer, Ballo-Toure; Bennacer, Tonali; Saelemaekers, Krunic, Leao; Giroud
Milan bench: Desplanches, Jungdal, Ibrahimovic, Romagnoli, Kalulu, Maldini, Bakayoko, Gabbia
Ref: Brych (GER