Napoli seek a 12th consecutive victory in all competitions, looking to Giovanni Simeone and Giacomo Raspadori against Glasgow Rangers.
It kicks off at 20.00 UK time (19.00 GMT) at the Stadio Diego Armando Maradona.
The Partenopei have already qualified for the Champions League Round of 16, so this is to secure top spot ahead of Liverpool and in theory an easier draw in the knockout stages.
Amir Rrahmani is the only remaining absentee, but Luciano Spalletti rotates the squad with Simeone flanked by Matteo Politano and Raspadori, while Kvicha Kvaratskhelia and Piotr Zielinski are rested.
Napoli have won 11 games in a row and have a 100 per cent Champions League record, in which they scored 17 goals in just four matches, including a 3-0 victory in Glasgow.
Rangers could in theory still fight Ajax for third place and Europa League qualification, but make the trip without Connor Goldson, Thomas Lawrence, John Souttar and Glen Kamara.
Because the Napoli fans were barred from travelling for the game at Ibrox, Rangers supporters are in turn banned from the Stadio Maradona.
Napoli: Meret; Di Lorenzo, Ostigard, Kim Min-jae, Mario Rui; Ndombele, Lobotka, Elmas; Politano, Simeone, Raspadori
Rangers: McGregor; Tavernier, King, Davies, Ridvan Yilmaz; Lundstram, Sands; Wright, Tillman, Kent; Morelos
Ref: Meler (TUR)