Napoli have a 2-0 first leg lead against Eintracht Frankfurt, looking to Victor Osimhen and Kvicha Kvaratskhelia for an historic first ever foray into the Champions League quarter-finals.
It kicks off at the Stadio Diego Armando Maradona at 20.00 GMT.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The Partenopei won the first leg 2-0 in Germany thanks to Osimhen and Giovanni Di Lorenzo goals, after Kvaratskhelia saw an early penalty saved.
Alex Meret, Kim Min-jae and Hirving Lozano have all shaken off knocks, so only Giacomo Raspadori is out of action, but Matteo Politano starts.
Randal Kolo Muani was sent off in the first leg and is therefore suspended, with Jesper Lindstrom injured.
Eintracht Frankfurt won the Europa League last season, but currently sit sixth in the Bundesliga and managed only two draws in their last four competitive games.
The away goals rule has been scrapped, so if Napoli lose by any two-goal margin, it goes to extra time.
There was controversy because local authorities banned entry to those born in or registered as residents of Frankfurt due to fears over crowd trouble.
Several hundred made the journey anyway, helped by an alliance with Atalanta ultras, who have a bitter rivalry with Napoli, and there were already attacks on Italian police in the streets today.
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Mario Rui; Anguissa, Lobotka, Zielinski; Politano, Osimhen, Kvaratskhelia
Napoli bench: Idasiak, Gollini, Juan Jesus, Elmas, Lozano, Olivera, Simeone, Bereszynski, Ostigard, Gaetano, Ndombele
Eintracht Frankfurt: Trapp; Tuta, Buta, N’Dicka; Knauff, Rode, Sow, Lenz; Gotze, Kamada; Borré
Eintracht bench: Ramaj, Horz, Smolcic, Jakic, Alidou, Toure, Hasebe, Alario, Chandler, Max
Ref: Taylor (ENG)
(Assist: Matteo Politano)
(Assist: Giovanni Di Lorenzo)