Juventus are under intense pressure to get the victory away to Maccabi Haifa and bring Angel Di Maria back with Dusan Vlahovic and Juan Cuadrado.
It kicks off in Haifa at 17.45 UK time (16.45 GMT).
You can follow all the build-up and action as it happens from this game and Milan-Chelsea on the LIVEBLOG.
The Bianconeri are right back in crisis mode after Saturday’s 2-0 Serie A defeat to Milan, and in Europe continue to play catch-up, already four points adrift of joint leaders PSG and Benfica.
Failure to pick up a victory in Israel would practically doom them to an early Champions League exit.
Di Maria was suspended against Milan and returns here, having already provided a hat-trick of assists in last week’s 3-1 win over Maccabi Haifa in Turin.
Arkadiusz Milik is still not 100 per cent fit, so Vlahovic and Cuadrado complete the trident in a 4-3-3 formation, which could also switch to a 4-4-2 system.
Gleison Bremer is rested, while Mattia De Sciglio, Federico Chiesa, Paul Pogba and Kaio Jorge are injured.
Daniele Rugani starts in central defence with captain Leonardo Bonucci.
Maccabi Haifa are on zero points so far and go into this game without injured Suf Podgoreanu, Yosef Raz Meir and Mahmoud Jaber, while Dolev Haziza is also not fully fit.
Maccabi-Juventus: confirmed line-ups
Maccabi Haifa: Cohen; Sundgren, Batubinsika, Goldberg, Cornud; Mohamed, Lavi, Chery; Pierrot, Atzili, David.
Juventus: Szczesny; Danilo, Rugani, Bonucci, Alex Sandro; Rabiot, Paredes, McKennie; Cuadrado, Vlahovic, Di Maria.