Napoli want to complete a perfect Champions League group stage visiting Anfield with Victor Osimhen and Kvicha Kvaratskhelia, while Liverpool start Mohamed Salah and Roberto Firmino.
It kicks off at 20.00 GMT.
Both teams have already qualified for the Round of 16 and Napoli will top the group as long as they don’t lose here by four clear goals.
They are seeking a 14th consecutive victory in all competitions, having crushed the Reds 4-1 back on September 7, and could make it a 100 per cent record in the group stage.
Amir Rrahmani is the only absentee, with Osimhen flanked by Kvaratskhelia and Matteo Politano, though the Italian is a booking away from suspension.
Piotr Zielinski is rested in favour of a more muscular midfield.
Liverpool have been stuttering so far this season and are coming off back-to-back Premier League defeats to Nottingham Forest and Leeds United.
Jurgen Klopp has to do without injured Luis Diaz, Diogo Jota, Joel Matip and Juventus loanee Arthur Melo, but still have Mohamed Salah and Bobby Firmino, benching €80m signing Darwin Nunez.
Liverpool: Alisson; Alexander-Arnold, Konaté, Van Dijk, Tsimikas; Milner, Fabinho, Thiago Alcantara; Jones; Salah, Firmino
Napoli: Meret; Di Lorenzo, Kim, Ostigard, Olivera; Ndombele, Lobotka, Anguissa; Politano, Osimhen, Kvaratskhelia
Ref: Stieler (GER)