Inter go with Alexis Sanchez, Lautaro Martinez and Arturo Vidal at Anfield in the second leg of the Champions League Round of 16, while Liverpool pick Sadio Mane with Diogo Jota and Mohamed Salah.
It kicks off at 20.00 GMT and the Reds won the first leg 2-0 at San Siro.
You can follow all the build-up and action as it happens on the LIVEBLOG.
The away goals rule does not apply, so if the two teams are level on aggregate, it will go to extra time or even penalties.
Just like the first leg, Nicolò Barella is suspended and a huge loss in midfield, replaced by veteran Arturo Vidal.
Coach Simone Inzaghi opts for a change upfront, bringing in Alexis Sanchez to partner Lautaro Martinez rather than Edin Dzeko.
Lautaro Martinez has not scored in Europe for almost a year, but he broke his 10-match goal drought on Friday with a hat-trick in the 5-0 win over Salernitana.
Robin Gosens and Joaquin Correa are available on the bench after long-term injuries.
Liverpool went into this game with fitness doubts for Roberto Firmino, Joel Matip and Thiago Alcantara, but the latter two both start.
January signing Luis Diaz is on the bench, so Sadio Mane completes the trident attack with Diogo Jota and former Roma and Fiorentina forward Salah.
Liverpool: Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Jones, Fabinho, Thiago Alcantara; Salah, Diogo Jota, Mané
Liverpool bench: Adrian, Kelleher, Milner, Keita, Gomez, Henderson, Oxlade-Chamberlain, Minamino, Tsimikas, Luis Diaz, Origi, Elliott
Inter: Handanovic; Skriniar, De Vrij, Bastoni; Dumfries, Vidal, Brozovic, Calhanoglu, Perisic; Alexis Sanchez, Lautaro Martinez
Inter bench: Cordaz, Radu, Gagliardini, Vecino, Dzeko, Ranocchia, Gosens, Correa, Dimarco, D’Ambrosio, Darmian, Caicedo