Juventus are decimated by injuries and bans, so Arkadiusz Milik starts with support from Fabio Miretti and Nicolò Fagioli against PSG’s Gianluigi Donnarumma, Marco Verratti, Lionel Messi and Kylian Mbappé.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 GMT.
You can follow all the build-up and action as it happens from this game and Milan-RB Salzburg on the LIVEBLOG.
The Bianconeri are already out of contention for the Champions League Round of 16, but that doesn’t mean there isn’t still plenty to play for.
They are currently level on three points with Maccabi Haifa and only ahead on overall goal difference in the battle for a Europa League spot.
The same is true at the top, where PSG and Benfica also have an identical head-to-head record, so group leadership could go down to goal difference.
Max Allegri is missing 10 players, although really it’s more because Federico Chiesa is in the squad for the first time since the ACL tear 10 months ago, but is not ready to play.
Danilo is suspended, with Moise Kean, Dusan Vlahovic, Angel Di Maria, Leandro Paredes, Gleison Bremer, Weston McKennie, Paul Pogba, Mattia De Sciglio and Samuel Iling-Junior all injured.
Fagioli scored a stunning debut Serie A goal to beat Lecce at the weekend and is given this first start.
As for Paris Saint-Germain, Neymar sits out a ban, with Presnel Kimpembe and Keylor Navas on the treatment table.
Carlos Soler therefore steps in with Messi and Mbappé, plus Italy internationals Donnarumma and Verratti.
Juventus: Szczesny; Gatti, Bonucci, Alex Sandro; Cuadrado, Fagioli, Locatelli, Rabiot, Kostic; Miretti; Milik
PSG: Donnarumma; Hakimi, Marquinhos, Sergio Ramos, Bernat; Verratti, Fabian Ruiz, Vitinha; Soler; Messi, Mbappé
Ref: Del Cerro Grande (ESP)