Arkadiusz Milik is only fit for the bench, so Dusan Vlahovic is partnered by Angel Di Maria as Juventus simply must get their first Champions League win against Maccabi Haifa.
It kicks off at the Allianz Juventus Stadium in Turin at 20.00 UK time (19.00 GMT).
The Bianconeri had a disastrous start to the season in Serie A and Europe, losing both their Champions League fixtures against PSG and Benfica, sitting six points adrift of the qualifying spots.
They got back on track domestically at the weekend, beating Bologna 3-0, but make changes because Milik is not fully fit, while Di Maria is in the middle of a two-match Serie A ban.
Wojciech Szczesny made his comeback last week, so only Paul Pogba, Federico Chiesa and Kaio Jorge remain on the treatment table.
Bremer and Danilo are the centre-backs, sending Leonardo Bonucci to the bench in a switch to the 4-3-3 formation.
Maccabi Haifa are also on zero points and have the added concern that because today is Yom Kippur, the day of atonement, many of their Jewish athletes have been fasting.
Forward Suf Podgoreanu is out injured, so Frantdzy Pierrot leads the line.
Juventus: Szczesny; Cuadrado, Bremer, Danilo, De Sciglio; McKennie, Paredes, Rabiot; Di Maria, Vlahovic, Kostic
Maccabi Haifa: Cohen; Mohamed, Sundgren, Batubinsika, Goldberg, Cornud; Chery, Seck, Abu Fani; Pierrot, Tchibota
Ref: Schärer (SUI)