Inter pick Edin Dzeko alongside Lautaro Martinez with support from Marcelo Brozovic in the Champions League quarter-final, boasting a 2-0 first leg lead over Benfica.
It kicks off at San Siro at 20.00 UK time (19.00 GMT).
You can follow all the build-up and action as it happens on the LIVEBLOG.
There is no away goals rule in Europe this season, so if Benfica manage to win by two clear goals and level the tie on aggregate, it goes to extra time.
The winners will face Milan in the semi-final, so we could see a repeat of the 2002-03 Derby della Madonnina.
Nicolò Barella and Romelu Lukaku scored in Lisbon, but the striker is left on the bench in favour of Dzeko as partner to Lautaro Martinez.
Milan Skriniar is out of action, while Brozovic is picked in midfield rather than returning Hakan Calhanoglu.
Although they are flourishing in Europe and the Coppa Italia, their Serie A form is dismal, meaning failure here could see Simone Inzaghi sacked.
Benfica aren’t faring much better in terms of timing, because they had been unbeaten in the Champions League before the home defeat to Inter, dropping points only in a pair of 1-1 group phase draws with PSG.
Now they have lost their last three matches in all competition.
Nicolas Otamendi was suspended for the first leg and returns to the defence here, while Ristic is also available again on the bench.
Jonathan Bah and Julian Draxler are long-term absentees and it remains a special match for former Inter flop Joao Mario, who was often jeered playing in this stadium even with the Nerazzurri jersey on.
The following players will be suspended if they receive a yellow card: Alessandro Bastoni, Federico Dimarco, Edin Dzeko, Lautaro Martinez, Goncalo Ramos, Florentino and Joao Mario.
Inter: Onana; Darmian, Acerbi, Bastoni; Dumfries, Barella, Brozovic, Mkhitaryan, Dimarco; Lautaro Martinez, Dzeko
Inter bench: Handanovic, Cordaz, Gagliardini, De Vrij, Gosens, Correa, Bellanova, Asllani, Calhanoglu, D’Ambrosio, Carboni, Lukaku
Benfica: Vlachodimos; Gilberto, Antonio Silva, Otamendi, Grimaldo; Chiquinho, Florentino; Joao Mario, Rafa Silva, Aursnes; Goncalo Ramos
Benfica bench: Samuel Soares, Andre Gomes, Verissimo, Neres, Goncalo Guedes, Tengstedt, Schjelderup, Ristic, Musa, N’Dour, Joao Neves, Morato
Ref: Del Cerro Grande (ESP)
Player statistic
| Nicolò Barella (Assist: Lautaro Martínez) |
 |
14' | ||
| 38' | |
Fredrik Aursnes (Assist: Rafa) |
| 49' |  |
Rafa | ||
| Lautaro Martínez (Assist: Federico Dimarco) |
|
65' | ||
| Joaquín Correa (Assist: Federico Dimarco) |
|
78' | ||
| 81' | |
Petar Musa | ||
| 86' | |
António Silva (Assist: Alejandro Grimaldo) | ||
| 90+5' | |
Petar Musa | ||
| 90+5' | |
David Neres |
Match statistic
