Charles De Ketelaere supports Rafael Leao and Olivier Giroud, as Milan face a very tough Champions League trip to Dinamo Zagreb.
It kicks off at the Stadion Maksimir at 20.00 UK time (19.00 GMT).
The Rossoneri have only four points after four games, the same as Dinamo Zagreb, but it remains a very balanced group with RB Salzburg on six and Chelsea seven.
If they lose and Salzburg win, Stefano Pioli’s men cannot reach the Round of 16.
Fikayo Tomori is suspended following his controversial early red card against Chelsea, with Mike Maignan, Sergino Dest, Davide Calabria, Alessandro Florenzi, Zlatan Ibrahimovic and Alexis Saelemaekers injured.
Brahim Diaz is only fit enough for the bench after a muscular problem and his splendid brace in Saturday’s 4-1 win over Monza.
Yacine Adli, Malick Thiaw, Aster Vranckx and Tiemoue Bakayoko are not eligible for the Champions League.
It all means Pioli has precious few choices to make, using Ante Rebic unusually on the right with De Ketelaere central, plus Simon Kjaer and Matteo Gabbia as centre-backs.
Dinamo Zagreb are unbeaten at home in the Champions League this season, defeating Chelsea 1-0 and holding RB Salzburg 1-1.
They lost 3-1 at San Siro on September 14 and have a full squad to choose from.
Mislav Orsic is their top scorer with two goals in four games.
Dinamo Zagreb: Livakovic; Ristovski, J Sutalo, Peric; Moharrami, Ademi, J Misic; Spikic, Ivanusec, Ljubicic; Orsic, Petkovic
Milan: Tatarusanu; Kalulu, Gabbia, Kjaer, Theo Hernandez; Bennacer, Tonali; Rebic, De Ketelaere, Leao; Giroud
Ref: Marciniak (POL)