Napoli could take a huge step towards qualification in Amsterdam with Giacomo Raspadori and Kvicha Kvaratskhelia, while Ajax rely on Dusan Tadic and impressive Mohammed Kudus.
It kicks off at the Amsterdam Arena at 20.00 UK time (19.00 GMT).
The Partenopei are top of their group with a 100 per cent record, as well as current joint Serie A leaders with Atalanta, so feel confident even without injured Victor Osimhen.
Raspadori gets the nod with Kvaratskhelia and this time Hirving Lozano rather than Matteo Politano completing the trident, but Giovanni Simeone is benched again.
Ajax are missing Ahmetcan Kaplan, Jorge Sanchez and troubled former Juventus and Sampdoria player Mohamed Ihattaren.
Tadic as usual leads the way as captain, but it’s his young teammate Mohammed Kudus who has been stealing the headlines with seven goals in 11 games this season, including two Champions League stunners.
Ajax: Pasveer; Rensch, J Timber, Bassey, Blind; Berghuis, Alvarez, Taylor; Tadic, Kudus, Bergwijn
Napoli: Meret; Di Lorenzo, Rrahmani, Kim Min-jae, Olivera; Anguissa, Lobotka, Zielinski; Lozano, Raspadori, Kvaratskhelia
Ref: Letexier (FRA)
If Liverpool can beat them then Napoli should.
They did and can’t wait for the home game.