Inter host Viktoria Plzen at the Stadio Meazza today with Lautaro Martinez and Edin Dzeko expected to start up front.
It kicks off at 17.45 UK time.
Inter will qualify for the Round of 16 with a game to spare with a victory. Barcelona-Bayern Munich, the other Champions League Group C match, starts at 20.00 UK time.
Marcelo Brozovic is the only injured player for the Nerazzurri. Romelu Lukaku is available but starts on the bench. The Belgium international hasn’t played a competitive game since the end of August.
Stefan de Vrij is favourite over Francesco Acerbi in centre defence, Federico Dimarco over Robin Gosens on the left.
Inter boss Simone Inzaghi is suspended so his assistant Massimiliano Farris will give instructions to the team from the touchline.
Inter could qualify for the Champions League Round of 16 for the second season in a row.
Inter-Viktoria Plzen: probable line-ups
Inter (3-5-2): Onana; Skriniar, De Vrij, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Lautaro Martinez, Dzeko.
Viktoria (4-2-3-1): Stanek; Havel, Hejda, Pernica, Jemelka; Kalvach, Bucha; Jirka, Vlkanova, Mosquera; Chory.