Inter can set up a Champions League semi-final Derby della Madonnina with a positive result against Primeira Liga leaders Benfica.
The match between the Nerazzurri and As Aguias kicks off at 20:00 UK time at the Stadio Giuseppe Meazza in Milan.
Simone Inzaghi’s side secured a vital 2-0 win over Benfica in the first leg of their quarter-final clash, with goals from Nicolo Barella and Romelu Lukaku allowing Inter to dream of a spot in the Champions League semi-finals.
The Nerazzurri are without defender Milan Skriniar, who is still struggling with a back injury. Benfica cannot count on Julian Draxler, who is still recovering from an ankle operation.
The other tie on this side of the bracket saw Milan edge out a 2-1 aggregate win over Napoli, giving Inter the chance to play for a spot in the final in one of the most important Derby della Madonnina clashes in years.
Probable line-ups for Inter vs Benfica
Inter (3-5-2): Onana; Darmian, Acerbi, Bastoni; Dumfries, Barella, Calhanoglu, Mkhitaryan, Dimarco; Dzeko, Lautaro.
Benfica (4-2-3-1): Vlachodimos; Gilberto, Antonio Silva, Otamendi, Grimaldo; Florentino, Chiquinho; Joao Mario, Rafa Silva, Aursnes; Gonçalo Ramos.