Ciro Immobile will be looking to end his goal drought against Celtic while Lazio seek a much-needed Champions League win after a poor start to the season.
It kicks off at 20:00 BST at Celtic Park.
The Bianconcelesti have only won two of their opening seven Serie A games this term, collecting a 1-1 draw against Atletico Madrid in their Champions League debut at home two weeks ago. Maurizio Sarri can rely on full squad at the Celtic Park tonight.
Captain Immobile partially rested against Milan on Saturday being introduced as a substitute in the second half at the Stadio Meazza. He has only scored two goals in eight appearances this season, the last on September 23.
The Italian will start with Mattia Zaccagni in attack tonight, while Felipe Anderson is favourite over Gustav Isaksen to fill the third spot up front.
There are a few more doubts in central midfield, with Matias Vecino and Daichi Kamada expected to start with Luis Alberto, leaving Matteo Guendouzi and Danilo Cataldi initially on the bench.
Luca Pellegrini or Elseid Hysaj will start as left-back, while Patric will join Alessio Romagnoli in central defence.
Celtic-Lazio, probable line-ups
Celtic (4-3-3): Hart; Ralston, Johnston, Scales, Taylor; O’Riley, McGregor, Hatate; Maeda, Furuhashi, Palma.
Lazio (4-3-3): Provedel; Marusic, Patric, Romagnoli, Pellegrini; Kamada, Vecino, Luis Alberto; Felipe Anderson, Immobile, Zaccagni.