Inter are vying for a first-place finish in their Champions League group and will be looking for all three points in their outing against Benfica.
The match between the Portuguese side and the Nerazzurri kicks off at 20.00 UK time at the Estadio da Luz in Lisbon.
Inter have already secured their spot in the Champions League knockout stages, holding a seven-point lead over third place RB Salzburg with two games left to play.
Simone Inzaghi’s side can now fight for the top spot in Group D with Real Sociedad, which’ll likely give an easier draw in the Round of 16. The Nerazzurri edged out a tense 1-0 win over Benfica in their first meeting at the start of October.
Benfica are without David Neres, Goncalo Guedes, Juan Bernat and Alexander Bah, all of whom are sidelined with injuries.
Inter cannot count on the injured Alessandro Bastoni and Benjamin Pavard, and Denzel Dumfries is also in doubt.
Probable line-ups for Benfica vs Inter
Benfica (4-2-3-1): Trubin; Aursnes, Antonio Silva, Otamendi, Morato; Florentino, Joao Neves; Di Maria, Rafa Silva, Joao Mario; Tengstedt.
Inter (3-5-2): Audero; Bisseck, De Vrij, Acerbi; Darmian, Frattesi, Asllani, Klaassen, Carlos Augusto; Arnautovic, Sanchez.