Lazio have the chance to secure a first-place finish in their Champions League group when they travel to face Atletico Madrid.
The match between los Colchoneros and the Biancocelesti kicks off at 20.00 UK time at the Estadio Metropolitano in Madrid.
Lazio and Atletico are neck and neck in Group E, with the former sat second with 10 points and the latter just ahead with 11. Both teams have already booked their spot in the knockout stages and are now competing to finish first in the group, which should set up an easier Round of 16 outing.
The Spanish side are without the injured Pablo Barrios and Thomas Lemar, and Diego Simeone may not risk Samuel Lino, who is a booking away from a one-game suspension.
Alessio Romagnoli and Gustav Isaksen are both unavailable for Lazio through injuries, whilst Nicolo Rovella is suspended after picking up three yellow cards.
When these two teams met back in September, Lazio held Atletico to a 1-1 draw after a sensational last-minute equaliser from goalkeeper Ivan Provedel.
Probable line-ups for Atletico Madrid vs Lazio
Atletico Madrid (3-5-2): Oblak; Savic, Witsel, Hermoso; Molina, De Paul, Koke, Griezmann, Riquelme; Morata, Correa.
Lazio (4-3-3): Provedel; Lazzari, Casale, Gila, Marusic; Guendouzi, Vecino, Luis Alberto; Felipe Anderson, Castellanos, Zaccagni.